HCID 69685147, compound → HCID 69685014, compound

Participants

Reaction Steps

A solution of (E)-3-(5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-acrylic acid ethyl ester (Intermediate 74, 0.97 g, 2.98 mmol) in 13 mL of ethyl acetate was treated with a slurry of 10% palladium on carbon (0.25 g) in 7 mL of ethanol and the resulting reaction mixture was stirred overnight under an atmosphere of hydrogen. The solids were then filtered over a bed of celite and the filtrate was evaporated to an oil. The oil was dissolved in dichloromethane and washed with water. The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to afford the title compound as a pale yellow oil (0.71 g, 96%).

Provenance & Evidence