Bromine → HCID 69684695, compound

Participants

Reaction Steps

A stirred, cooled (ice bath) solution of 3-(3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-propionic acid ethyl ester (Intermediate 75, 0.71 g, 2.86 mmol) in ethanol (14 mL) was treated with bromine (0.3 mL, 5.819 mmol) and the reaction mixture was allowed to gradually warm up to room temperature over 1.5 h. The volatiles were then evaporated in vacuo and the residue was dissolved in diethyl ether and washed with water (×1), aqueous sodium thiosulfate solution (×1) and brine (×1), dried over anhydrous sodium sulfate, filtered and evaporated to afford the title compound as an oil (0.875 g, 93%).

Provenance & Evidence