Lithium hydroxide, monohydrate → HCID 22731315, compound

Participants

Reaction Steps

A solution of 3-(5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-propionic acid ethyl ester (Intermediate 76, 0.875 g, 2.67 mmol) in methanol (15 mL), tetrahydrofuran (15 mL) and water (7 mL) was treated with lithium hydroxide monohydrate (0.68 g, 16 mmol) and the resulting reaction mixture was stirred at room temperature for 1 h. The volatiles were evaporated in vacuo and the residue was diluted with water and washed with diethyl ether. The aqueous phase was neutralized with concentrated hydrochloric acid and the solution was extracted with ether (×3). The combined organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated to afford the title compound as an oily foam (0.64 g, 87%).

Provenance & Evidence