Dimethylamine → HCID 22731316, compound

Participants

Reaction Steps

A stirred, cooled (−78° C.) solution of 3-(5-bromo-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl)-propionic acid (Intermediate 77, 0.7 g, 2.34 mmol) and triphenyl phosphine (0.74 g, 2.81 mmol) in anhydrous benzene (10 mL) and dichloromethane (20 mL) was treated with hexachloroacetone (0.178 mL, 1.17 mmol). After 1 h, a 2M solution of dimethyl amine in tetrahydrofuran (3 mL, 6 mmol) was added. After 1 h, the reaction mixture was evaporated in vacuo to a brown oil which was subjected to flash column chromatography using 40% ethyl acetate in hexane as the eluent to afford the title compound (0.65 g, 84%).

Provenance & Evidence