Diiodomethane → HCID 69921920, compound

Participants

Reaction Steps

Following General Procedure C and using 1.57M diethylzinc in anhydrous dichloromethane (10 mL, 15.7 mmol), 1,2-dimethoxyethane (1.63 mL, 15.7 mmol), diiodomethane (2.53 mL, 31.4 mmol), 1-[5-((Z)-3-hydroxy-1-methyl-propenyl)-3,3-dimethyl-2,3-dihydro-benzofuran-7-yl]-heptan-3-one (Intermediate 800.18 g, 0.55 mmol), 4A° molecular sieves powder (0.4 g) and (4S-trans)-2-butyl-N,N,N′,N′-tetramethyl[1,3,2]dioxaborolane-[4,5]dicarboxamide (0.34 g, 1.17 mmol) in 3 mL of anhydrous dichloromethane followed by flash column chromatography using 20% ethyl acetate in hexane, the title compound was obtained as a brown oil (0.16 g,85%). It was used as such for the next step.

Provenance & Evidence