Vinyl isobutyl ether → HCID 86759419, compound

Participants

Reaction Steps

A catalytic amount of pyridinium para-toluenesulfonate was added to 5.9 g (0.05 mole) of methyl (S)-(+)-3-hydroxy-2-methylpropionate. Thereto was dropwise added 5.5 g (0.055 mole) of isobutyl vinyl ether at room temperature. Then, stirring was conducted at room temperature for 4 hours to give rise to a reaction. Thereto was added 100 ml of toluene. The resulting mixture was washed with 50 ml of a 0.1% aqueous sodium hydroxide solution and 20 ml of water in this order. The washed material was subjected to vacuum distillation to remove the solvent, whereby was obtained 10.5 g (yield: 97.0.%) of an oily title compound (diastereomixture).

Provenance & Evidence