N-tert-Butylglycine → HCID 131724405, compound

HRID 2085633Notes

Reaction equation

HRID 2085633 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([NH:22][CH2:23][CH2:24]Cl)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:5].C([NH:30][CH2:31][C:32]([OH:34])=[O:33])(C)(C)C>>[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([NH:22][CH2:23][CH2:24][NH:30][CH2:31][C:32]([O:34][C:3]([CH3:18])([CH3:4])[CH3:2])=[O:33])=[CH:18][C:3]=1[C:4](=[O:5])[NH:6][CH2:7][C:8]12[CH2:9][CH:10]3[CH2:16][CH:14]([CH2:13][CH:12]([CH2:11]3)[CH2:17]1)[CH2:15]2

Participants

3

Reactant 2

HCID 414246N-tert-ButylglycineHCID 114176532-Chloro-5-(2-chloroethyl)amino-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)benzamide

Product 1

HCID 131724405HCID 131724405, compoundYield 80.1%

Procedure

Prepared according to the method of Example 1 using 2-chloro-5-(2-chloroethyl)amino-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (WO 99/29661) (0.2 g) and tertbutyl glycine (0.26 g) to deliver the sub-title compound as a brown foam (0.10 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ca7037e5f7d94bf78e3369ad56cb8cfd
Source dataset
uspto-grants-2004_04
Patent number
US06720452B2

Reaction notes

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