Sulfuric acid magnesium salt (1:1) → HCID 131724408, compound

Participants

Reaction Steps

Prepared according to the method of Example 22 from [2-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]amino]ethyl][2-(methylthio)ethyl]-carbamic acid, 1,1-dimethylethyl ester (0.460 g, Example 30a), 3-chloroperoxybenzoic acid (0.315 g) and dichloromethane (20 ml). Excess calcium hydroxide was added, followed by excess magnesium sulfate. The mixture was filtered through celite and concentrated under reduced pressure. The crude material was purified on silica gel (19:1/dichloromethane:methanol) to afford the sub-title compound as a gum (0.141 g) and the corresponding sulfone (0.057 g).

Provenance & Evidence