HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(4,4-DIMETHYLPIPERIDIN-1-YL)BENZOIC ACID
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 4-(4,4-dimethylpiperidin-1-yl)benzoate | HCID 11651829 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(4,4-DIMETHYLPIPERIDIN-1-YL)BENZOIC ACID | HCID 11535980 | — |
Reaction Steps
A solution of Example 119B (260 mg, 1.0 mmol) and LiOH.H2O (158 mg, 4.0 mmol) in THF (19 mL), water (5 mL), and methanol (5 mL) was heated to 75° C. for 18 hours, cooled to room temperature, concentrated, and adjusted to pH 3-4 with 1N HCl. The precipitate was collected by filtration, washed with water, and dried under vacuum to provide the desired product. MS(DCI(+)) m/e 234 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06720338B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-6230f0c2b66e4024b1be85af5a0f7af6 |
| Source note | uspto-grants-2004_04 |