HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2085714Generated: November 2, 2026
Water → Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate
https://huagongshe.com/reaction/2085714
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Ethyl 4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)benzoate | HCID 12717439 | — |
Reaction Steps
A mixture of ethyl 4-fluorobenzoate (6.0 mL, 41 mmol), 1,4-dioxa-8-azaspiro(4,5)decane (13.5 mL, 102 mmol), and K2CO3 (5.7 g, 41 mmol) in NMP (35 mL) was stirred at 150° C. for 4 hours, cooled to room temperature, treated with water (0.5 L) and filtered. The filter cake was washed with water and dried briefly. The crude product was triturated with hexane, filtered, and dried under vacuum to provide the desired product. MS (DCI) m/e 292 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06720338B2 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-b3ad51467da24261a7e0ea4d4d28abbc |
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| Source note | uspto-grants-2004_04 |
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