Benzocaine → HCID 5199623, compound

HRID 2085746Notes

Reaction equation

[C:1]1(=O)[O:6][C:4](=[O:5])[CH2:3][CH2:2]1.[NH2:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16]C)=[O:14])=[CH:11][CH:10]=1.CC1(C)CC(=O)OC(=O)C1>>[O:5]=[C:4]1[CH2:3][CH2:2][C:1](=[O:6])[N:8]1[C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][CH:10]=1

Participants

Reactant 3

HCID 2337Benzocaine

HCID 7922Succinic anhydride

HCID 778133,3-Dimethylglutaric anhydride

Product 1

HCID 5199623HCID 5199623, compound

Procedure

The desired product was prepared by substituting methyl 4-aminobenzoate and succinic anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 119A. MS (DCI) m/e 251 (M+NH4)+.

Sources & evidence

ORD record: ord-991f19f4ee2d40968ecc53bd181ac068
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06720338B2

Reaction notes

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