HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2085764Generated: October 31, 2026
Potassium Carbonate → HCID 54705574, compound
https://huagongshe.com/reaction/2085764
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-iodobenzoate | HCID 69273 | — |
| Reactant | HCID 178516518 | HCID 178516518 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 54705574 | HCID 54705574 | — |
Reaction Steps
A mixture of methyl 4-iodobenzoate (0.421 g, 1.6 mmol), 2,4-dihydroxypyridine (0.174 g, 1.34 mmol), CuI (25 mg, 0.134 mmol) and K2CO3 (200 mg) in DMF (2 mL) was heated to 150° C. in a sealed vial for 4 hours, diluted with ethyl acetate (100 mL), washed with water (30 mL) and brine (30 mL), dried (Na2SO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 2:1 hexanes/ethyl acetate to provide the desired product. MS (APCI) m/e 246 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06720338B2 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-a9db259235714a10a7bc6c5a1da9619e |
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| Source note | uspto-grants-2004_04 |
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