Trimethylsilyldiazomethane → Methyl 4-bromo-3-fluorobenzoate

Participants

Reaction Steps

A solution of 4-bromo-3-fluorobenzoic acid (117 mg, 0.50 mmol) in methanol (1 mL) and dichloromethane (2 mL) at room temperature was slowly treated with 2M trimethylsilyldiazomethane in hexanes until the solution became light yellow. The mixture was concentrated to provide the desired product.

Provenance & Evidence