4-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-aniline → 2-(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide

HRID 208579Notes

Reaction equation

HRID 208579 reaction equation
[CH:21]([CH3:22])([CH3:23])[N:24]1[CH2:25][CH2:26][N:27]([CH2:30][c:31]2[c:32]([C:38]([F:39])([F:40])[F:41])[cH:33][c:34]([NH2:37])[cH:35][cH:36]2)[CH2:28][CH2:29]1.[Cl:1][c:2]1[c:3]([CH2:17][C:18](=[O:19])[OH:20])[cH:4][cH:5][c:6](-[n:8]2[cH:9][n:10][c:11]3[c:12]2[n:13][cH:14][cH:15][cH:16]3)[cH:7]1>>[Cl:1][c:2]1[c:3]([CH2:17][C:18](=[O:20])[NH:37][c:34]2[cH:33][c:32]([C:38]([F:39])([F:40])[F:41])[c:31]([CH2:30][N:27]3[CH2:26][CH2:25][N:24]([CH:21]([CH3:22])[CH3:23])[CH2:29][CH2:28]3)[cH:36][cH:35]2)[cH:4][cH:5][c:6](-[n:8]2[cH:9][n:10][c:11]3[c:12]2[n:13][cH:14][cH:15][cH:16]3)[cH:7]1

Participants

3

Reactant 2

HCID 574314454-(4-Isopropylpiperazin-1-ylmethyl)-3-trifluoromethyl-anilineHCID 67021590(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid

Product 1

HCID 119935802-(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-[4-(4-isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-acetamide

Sources & evidence

ORD record
ord-88644a16d18b4a7f9284aa4ac4916177
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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