HCID 22730621, compound → HCID 22730369, compound

HRID 2085819Notes

Reaction equation

HRID 2085819 reaction equation
C([O:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][C:20]([CH3:28])([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:19][CH2:18]2)=[CH:13][CH:12]=1)=[O:10])C1C=CC=CC=1>C(O)C.[Pd]>[CH2:26]([O:25][C:23]([C:20]1([CH3:28])[CH2:19][CH2:18][N:17]([C:14]2[CH:13]=[CH:12][C:11]([C:9]([OH:10])=[O:8])=[CH:16][CH:15]=2)[CH2:22][CH2:21]1)=[O:24])[CH3:27]

Participants

4

Reactant 1

HCID 22730621HCID 22730621, compound

Product 1

HCID 22730369HCID 22730369, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of Example 532E (0.54 g, 1.4 mmol) in ethanol (6 mL) at room temperature was hydrogenated at 60 psi over 10% Pd/C (58 mg) for 1.5 hours, filtered, and concentrated to provide the desired product. MS (DCI) m/e 292 (M+H)+.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a14733dde5ad496e986980abd46b0d2b
Source dataset
uspto-grants-2004_04
Patent number
US06720338B2

Reaction notes

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