Hydrogen Peroxide → HCID 12992472, compound

Participants

Reaction Steps

17β-Hydroxy-14α,15α-methylene-estr-4-ene-3-one (2 g) was dissolved in 50 ml of methanol and treated at 10° C. with hydrogen peroxide solution (35%). While stirring, 5 ml of a 10 sodium hydroxide solution was added and the stirring was continued for 3 hours. The reaction solution is mixed with 50 ml of dichloromethane and 25 ml of water and the organic phase is removed, washed with semi-concentrated thiosulfate solution, dried and evaporated to dryness. The residue obtained consists of a mixture of 4α,5α- and 4β,5β epoxides and is used in the subsequent step without further purification.

Provenance & Evidence