Bromine → 2,6-Difluorophenacyl bromide

HRID 2085915Notes

Reaction equation

HRID 2085915 reaction equation
[CH3:1][C:2]([C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[F:11])=[O:3].[Cl-].[Al+3].[Cl-].[Cl-].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH2:1][C:2]([C:4]1[C:5]([F:11])=[CH:6][CH:7]=[CH:8][C:9]=1[F:10])=[O:3]

Participants

5

Reactant 3

HCID 24408BromineHCID 836431-(2,6-Difluorophenyl)ethan-1-oneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 27782632,6-Difluorophenacyl bromide

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

40.6 g of 2,6-difluoroacetophenone are placed in 120 ml of chloroform, and 0.1 g of aluminium chloride is added. Then, at 0° C., 37 g of bromine in 240 ml of chloroform are added dropwise and stirring is carried out at 0° C. for 1 h. The reaction mixture is then heated to room temperature and is concentrated using a rotary evaporator. The residue is distilled over a Vigreux column. In this way 2-bromo-1-(2,6-difluorophenyl)-ethanone having a boiling point of 101-11° C. at 9 mbar is obtained.

Workup

  1. concentrationis concentrated
  2. customa rotary evaporator
  3. distillationThe residue is distilled over a Vigreux column

Sources & evidence

ORD record
ord-ab6e108662d2435aa647c363a9716f4e
Source dataset
uspto-grants-2004_04
Patent number
US06723720B2

Reaction notes

Loading…