1-(Benzenesulfonyl)-1H-indol-5-amine → N4-(1-Benzenesulphonyl-1H-indol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine hydrochloride

HRID 2085957Notes

Reaction equation

HRID 2085957 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([NH2:19])=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:20][C:21]1[C:22]2[CH:30]=[C:29]([N:31]([CH3:33])[CH3:32])[N:28]=[CH:27][C:23]=2[N:24]=[CH:25][N:26]=1>>[ClH:20].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([NH:19][C:21]4[C:22]5[CH:30]=[C:29]([N:31]([CH3:33])[CH3:32])[N:28]=[CH:27][C:23]=5[N:24]=[CH:25][N:26]=4)=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 154501451-(Benzenesulfonyl)-1H-indol-5-amineHCID 227274534-Chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine

Product 1

HCID 22727436N4-(1-Benzenesulphonyl-1H-indol-5-yl)-N6,N6-dimethyl-pyrido[3,4-d]pyrimidine-4,6-diamine hydrochloride

Procedure

Prepared according to Procedure A from 1-benzenesulphonyl-1H-indol-5-ylamine and 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine; δH [2H6]DMSO 11.64(1H,s), 8.90(1H,s), 8.60(1H,s), 8.05(4H,m), 7.90(1H,d), 7.65(5H,m), 6.92(1H,d), 3.20(6H,s); m/z (M+) 445.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0a385b51c7454f4aa38a28e4ab06dc4f
Source dataset
uspto-grants-2004_04
Patent number
US06723726B1

Reaction notes

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