1-(Phenylmethyl)-1H-indazol-5-amine → (1-Benzyl-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine Hydrochloride

HRID 2085960Notes

Reaction equation

HRID 2085960 reaction equation
[Cl:1][C:2]1[C:3]2[CH:11]=[C:10]([C:12]3[O:13][C:14]([CH3:17])=[N:15][N:16]=3)[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:18]([N:25]1[C:33]2[C:28](=[CH:29][C:30]([NH2:34])=[CH:31][CH:32]=2)[CH:27]=[N:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[ClH:1].[CH2:18]([N:25]1[C:33]2[C:28](=[CH:29][C:30]([NH:34][C:2]3[C:3]4[CH:11]=[C:10]([C:12]5[O:13][C:14]([CH3:17])=[N:15][N:16]=5)[N:9]=[CH:8][C:4]=4[N:5]=[CH:6][N:7]=3)=[CH:31][CH:32]=2)[CH:27]=[N:26]1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 2120691-(Phenylmethyl)-1H-indazol-5-amineHCID 22011950HCID 22011950, compound

Product 1

HCID 22727467(1-Benzyl-1H-indazol-5-yl)-(6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-amine Hydrochloride

Procedure

4-Chloro-6-(5-methyl-1,3,4-oxadiazol-2-yl) pyrido[3,4-d]pyrimidine (0.02 g) was reacted with 1-benzylindazol-5-ylamine according to Procedure A to give the title compound as a yellow solid; δH [2H6]DMSO 11.50(1H,s), 9.55(1H,s), 9.43 (1H,s), 8.95(1H,s), 8.34(2H,m), 7.91(1H,d), 7.83(1H,dd), 7.40(5H,m), 5.80 (2H,s), 2.75 (3H,s); m/z (M+1+) 435.

Sources & evidence

ORD record
ord-2401e4fb39344685b27f08310ddc73a5
Source dataset
uspto-grants-2004_04
Patent number
US06723726B1

Reaction notes

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