1,3-Dichloroacetone → HCID 22726753, compound

Participants

Reaction Steps

A solution of N-(2-t-butyloxycarbonylaminoethyl)thiourea (1.00 g, 4.54 mol) in ethanol (22 mL) was added 1,3-dichloroacetone (2.60 g, 20.47 mmol) at room temperature. After 2 hours the reaction mixture was concentrated under reduced pressure. The residue was triturated with ether and filtered to afford the solid precipitate of title product (1.40 g), which was used for next step without further purification. 1H NMR (CDCl3) δ 1.40 (s, 9H), 3.35 (m, 4H), 4.38 (s, 2H), 5.00 (br s, 1H), 6.40 (s, 1H).

Provenance & Evidence