N-(tert-butoxycarbonyl)-2-aminoethanethiol → HCID 22726895, compound

HRID 2085976Notes

Reaction equation

HRID 2085976 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][CH:14]=[C:15]([CH2:17]Cl)[N:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:19]([O:23][C:24]([NH:26][CH2:27][CH2:28][SH:29])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][CH:14]=[C:15]([CH2:17][S:29][CH2:28][CH2:27][NH:26][C:24]([O:23][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:25])[N:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 3017761N-(tert-butoxycarbonyl)-2-aminoethanethiolHCID 22726753HCID 22726753, compound

Product 1

HCID 22726895HCID 22726895, compound

Procedure

2-(2-t-butyloxycarbonylaminoethylamino)-4-chloromethyl-1,3-thiazole was reacted with 2-t-butyloxycarbonylaminoethanethiol in a manner similar to that described in Example 42. 1H NMR (CDCl3) δ 1.50 (s, 18H), 2.80 (m, 2H), 3.30-3.60 (m, 6H), 3.72 (s, 2H), 5.10 (br s, 1H), 5.40 (br s, 1H), 6.38 (s, 1H).

Sources & evidence

ORD record
ord-320a0b871e9e4c29b12b82538fe89d8a
Source dataset
uspto-grants-2004_04
Patent number
US06723716B1

Reaction notes

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