Potassium Phosphate, Tribasic → HCID 10133686, compound

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Reaction Steps

Prepared from the compound of Example 2 and isoindoline. To a solution of 2-chloro-N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-acetamide (45 mg) in N,N-dimethylformamide (10 mL) was added potassium phosphate (68 mg) and isoindoline (0.025 mL). The solution stirred at room temperature for 5 hours followed by evaporation of the solvent. The light brown product was washed with water and filtered (35 mg). 1H-NMR (300 MHz, DMSO-d6), 11.67 (br s, 1H), 9.97 (br s, 1H), 8.69 (s, 1H), 8.31 (d, J=9.0 Hz, 2H), 7.84 (m, 2H), 7.65 (t, J=9.0 Hz, 1H), 7.27 (m, 5H), 4.11 (s, 4H), 3.60 (s, 2H).

Provenance & Evidence