Dimethylformamide → HCID 22727943, compound

Participants

Reaction Steps

Prepared from the compound of Example 2 and N-methylcyclohexylamine. To a solution of 2-chloro-N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-acetamide (45 mg) in N,N-dimethylformamide (10 mL) was added potassium phosphate (68 mg) and N-methylcyclohexylamine (0.025 mL). The solution stirred at room temperature for 5 hours followed by evaporation of the solvent. The light brown product was washed with water and filtered (30 mg). 1H-NMR (300 MHz, DMSO-d6), 11.69 (br s, 1H), 9.76 (br s, 1H), 8.65 (s, 1H), 8.34 (t, 2H), 7.87 (m, 2H), 7.66 (t, 1H), 7.32 (t, 1H), 3.18 (s, 2H), 2.34 (s, 3H), 1.80 (m, 4H), 1.60 (m, 2H), 1.23 (m, 5H).

Provenance & Evidence