Hydrochloric Acid → HCID 45264345, compound

Participants

Reaction Conditions

Reaction Steps

Prepared from 2-(6(5H)-phenanthridinone)sulfonyl chloride 4 and 1-(2-aminoethyl)piperidine according to General Procedure A. A hydrogen chloride salt was formed upon adding 1N HCl to a solution of 5,6-dihydro-N-[2-(1-piperidinyl)ethyl]-6-oxo-2-phenanthridinesulfonamide in dioxane at 70° C. The was cooled down to 0° C. produced a salt precipitation which was collected by filtration to give a white solid (53% yield from 4), mp 262-267° C. 1H-NMR (400 MHz, CDCl3), 8.79 (s, 1H), 8.56 (d, J=8.1 Hz, 1H), 8.36 (d, J=7.2 Hz, 1H), 7.93 (m, 2H), 7.75 (t, J=7.5 Hz, 1H), 7.54 (d, J=8.7 Hz, 1H), 3.41 (d, J=12.2 Hz, 2H), 3.14 (m, 4H), 2.89 (t, 2H). 1.71 (m, 1H). Anal. (C20H24N3O3S.HCl.0.4 H2O), C H N.

Provenance & Evidence