HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → 7-bromo-5-nitro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | 7-Bromo-5-nitroindoline | HCID 323490 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 7-bromo-5-nitro-1H-indole | HCID 3860326 | 91.1% |
Reaction Steps
To a solution of 7-bromo-5-nitroindoline (3.0 g, 12.3 mmol) in 200 mL of acetone was added 2,3-dichloro-5,6-dicyano-1,4-benzoquinone until color of the solution turns to dark green. The reaction mixture was concentrated in vacuo and subjected to column chromatography (CHCl3, neat) to yield 2.7 g (11.2 mmol, 91%) of the indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723741B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-053cccf2d3734c8794d91970331c9573 |
| Source note | uspto-grants-2004_04 |