HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Methyl-5-nitro-1H-indole → 7-Methyl-1H-indol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Methyl-5-nitro-1H-indole | HCID 15453466 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-Methyl-1H-indol-5-amine | HCID 15434501 | 55% |
Reaction Steps
A solution of 7-methyl-5-nitroindole (0.35 g, 2.0 mmol) and 10% Pd/C (50 mg) in 20 mL of MeOH was stirred under H2. The reaction mixture was filtered and concentrated in vacuo, yielding an oil (0.16 g, 1.1 mmol, 41%), which was characterized by NMR and subjected to the following reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723741B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-bf674b86cc224a04ae3b3aff00f13e0f |
| Source note | uspto-grants-2004_04 |