反应详情

A suspension of 1-(3-nitrophenyl)pyrrolidin-2-one (3.0 g, 15 mmol) in ethanol (50 ml) was heated until complete solution was obtained. The solution was cooled to ambient temperature then treated with 10% palladium on charcoal (150 mg) and hydrogenated at 50 psi until hydrogen uptake ceased (ca. 2 hours). The mixture was filtered through a glass microfibre filter paper (Whatman GF/A) and evaporated to dryness to give 1-(3-aminophenyl)pyrrolidin-2-one as a pale green oil (2.6 g, 100%) which was used without purification.

1. temperaturewas heated until complete solution
2. customwas obtained
3. custom(ca. 2 hours)
4. filtrationThe mixture was filtered through a glass microfibre
5. filtrationfilter paper (Whatman GF/A)
6. customevaporated to dryness