4-(3-Nitrobenzyl)morpholine → 3-(Morpholin-4-ylmethyl)aniline

Participants

Reaction Steps

A solution of 4-(3-nitrobenzyl)morpholine (3.0 g, 14 mmol) in ethanol (40 ml) was treated with 10% palladium on charcoal (150 mg) and hydrogenated at 50 psi until hydrogen uptake ceased (ca. 2 hours). The mixture was filtered through a glass microfibre filter paper (Whatman GF/A) and evaporated to dryness to give 3-(morpholin-4-ylmethyl)phenylamine as a colourless oil (2.6 g, 100%) which was used without purification. m/z (ES+) 193 (M++H).

Provenance & Evidence