Trifluoroacetate → HCID 9820485, compound

HRID 2086086Notes

Reaction equation

HRID 2086086 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]3[N:14]=[CH:13][N:12]([C:15]4[CH:16]=[C:17](OS(C(F)(F)F)(=O)=O)[CH:18]=[CH:19][CH:20]=4)[C:9]3=[N:10][CH:11]=2)=[CH:2]1.[CH:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1B(O)O)=[O:30].FC(F)(F)C([O-])=O>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]3[N:14]=[CH:13][N:12]([C:15]4[CH:16]=[C:17]([C:32]5[C:31]([CH:29]=[O:30])=[CH:36][CH:35]=[CH:34][CH:33]=5)[CH:18]=[CH:19][CH:20]=4)[C:9]3=[N:10][CH:11]=2)=[CH:2]1

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 2921892-Formylphenylboronic acidHCID 86759422HCID 86759422, compound

Product 1

HCID 9820485HCID 9820485, compound

Procedure

The title compound was prepared from trifluoromethanesulphonic acid 3-[6-(furan-3-yl)imidazo[4,5-b]pyridin-3-yl]phenyl ester and 2-formylphenylboronic acid as described in Example 6. Trifluoroacetate salt (cream-coloured powder): δH (400 MHz, d6-DMSO) 7.10-7.11 (1H, m), 7.49 (1H, dt, J 8 and 1), 7.59-7.62 (2H, m), 7.70 (1H, t, J 8), 7.75-7.79 (2H, m), 7.93-7.95 (1H, m), 8.08-8.11 (2H, m), 8.33-8.34 (1H, m), 8.48 (1H, d, J 2), 8.76 (1H, d, J 2), 8.99 (1H, s), 9.99 (1H, s); m/z (ES+) 366 (M++H).

Sources & evidence

ORD record
ord-8c94e61540224df88adfc41d3e19fcbc
Source dataset
uspto-grants-2004_04
Patent number
US06723735B1

Reaction notes

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