HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| Reactant | 2-(2-Hydroxyphenyl)-4H-1,3-benzoxazin-4-one | HCID 135685723 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate | HCID 135914986 | — |
Reaction Steps
51.5 g of 2-(2-hydroxyphenyl)benz[e][1,3]oxazin-4-one, 30.5 ml of triethylamine and 33.4 g of ethyl hydrazinoacetate hydrochloride are boiled under reflux for 0.5 h in 450 ml of ethanol. On cooling, the product precipitates in crystalline form. It is filtered off and washed with ethanol. After drying, ethyl [3,5-bis(2-hydroxyphenyl)-(1,2,4]triazol-1-yl]acetate remains as colorless crystals of m.p. 172-174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723742B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-083ce9eb8b3a4fd09afac86ec97f3f6e |
| Source note | uspto-grants-2004_04 |