Ethanol → HCID 135817470, compound

HRID 2086105Notes

Reaction equation

HRID 2086105 reaction equation
O[C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:9]2[O:10][C:11]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][C:12]=3[C:13](=O)[N:14]=2)=[CH:4][CH:3]=1.[NH:21]([C:23]1[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=1)[NH2:22].C([OH:34])C>>[OH:34][C:4]1[CH:3]=[CH:2][C:7]([CH3:8])=[CH:6][C:5]=1[C:9]1[N:14]=[C:13]([C:12]2[CH:16]=[C:17]([CH3:20])[CH:18]=[CH:19][C:11]=2[OH:10])[N:21]([C:23]2[CH:24]=[CH:25][C:26]([C:27]([OH:29])=[O:28])=[CH:30][CH:31]=2)[N:22]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 120894-Hydrazinobenzoic acidHCID 136347702HCID 136347702, compound

Product 1

HCID 135817470HCID 135817470, compound

Procedure

1.15 g of 2-(6-hydroxy-m-tolyl)-6-methyl-4H-[1,3]benzoxazin-4-one in [CAS-Reg.-No.: 24798-62-7] and 0.6 g of 4-hydrazinobenzoic acid are boiled under reflux for 2 h in 15 ml of ethanol. The crystals precipitating on cooling are crystallized from isopropanol. After drying, 4-[3,5-bis(2-hydroxy-5-methylphenyl)-[1,2,4]triazol-1-yl]benzoic acid remains as colorless crystals of m.p. 268-269° C.

Workup

  1. customThe crystals precipitating
  2. temperatureon cooling
  3. customare crystallized from isopropanol
  4. customAfter drying

Sources & evidence

ORD record
ord-bcb9a1bfc0da4dbe90557d57b3877747
Source dataset
uspto-grants-2004_04
Patent number
US06723742B2

Reaction notes

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