HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate | HCID 135914986 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid | HCID 135817464 | — |
Reaction Steps
0.6 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) is dissolved in 20 ml of methanol with 0.4 g of sodium hydroxide and the mixture is stirred at room temperature for 2 h. It is acidified with 0.1 N hydrochloric acid and the precipitated crystals are filtered off. After washing with water and drying, [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetic acid remains as colorless crystals of m.p. 231-233 ° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723742B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-310549fbea9b4a7c921899742003ba67 |
| Source note | uspto-grants-2004_04 |