HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1,2-propanediol → 2-[3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2,3-dihydroxypropyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Reactant | Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate | HCID 135914986 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[3,5-Bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2,3-dihydroxypropyl)-acetamide | HCID 135817467 | — |
Reaction Steps
2.0 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) and 2.4 g of (±)3-amino-1,2-propanediol are heated at 60° C. for 2 h in 10 ml of ethanol. The crystals precipitating on cooling are filtered off and washed with ethanol. After drying, 2-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2,3-dihydroxypropyl)acetamide remains as colorless crystals of m.p. 180-181° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723742B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-4da0a866eb314263877c4dd24174fd90 |
| Source note | uspto-grants-2004_04 |