HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Deferasirox Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Deferasirox | HCID 214348 | — |
| Product | Deferasirox Ethyl Ester | HCID 135817477 | — |
Reaction Steps
10 g of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid (Example 5) and 0.5 ml of sulfuric acid are boiled under reflux for 20 h in 200 ml of ethanol. The crystals precipitating on cooling are crystallized from isopropanol/water. After drying, ethyl 4-[3,5-bis(2-hydroxy-phenyl)-[1,2,4]triazol-1-yl]benzoate is obtained as colorless crystals of m.p. 148-149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723742B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-5496170a3fff4020b878290f1e335406 |
| Source note | uspto-grants-2004_04 |