HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → (4-Fluorophenyl)[2-methoxy-5-(2,6-dimethyl-4-nitrophenoxy)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 4-(4-Methoxy-phenoxy)-3,5-dimethyl-nitrobenzene | HCID 10084672 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Product | (4-Fluorophenyl)[2-methoxy-5-(2,6-dimethyl-4-nitrophenoxy)phenyl]methanone | HCID 10046205 | — |
Reaction Steps
[5-(2,6-Dimethyl-4-nitro-phenoxy)-2-methoxy-phenyl]-(4-fluoro-phenyl)-methanone was prepared by titanium tetrachloride-catalyzed Friedel-Crafts acylation of 4-(4-methoxy-phenoxy)-3,5-dimethyl-nitrobenzene with p-fluorobenzoyl chloride according to the procedure described in the J. Med. Chem., 1995, 695-707.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723744B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-a8d5ba0000ff47628782e59cbacd3233 |
| Source note | uspto-grants-2004_04 |