HCID 69338225, compound → HCID 20721247, compound

Participants

Reaction Steps

(4R)-Methyl-4-[2-(thiophen-2-yl)ethenyl]oxazolidin-2-one (18.0 g, 86.0 mmol) obtained in Example 66(d) was dissolved in methanol (150 ml), and 10% palladium-charcoal (4.5 g) was added thereto followed by stirring for 10 hours at room temperature under a hydrogen atmosphere. The palladium-charcoal in the reaction solution was removed by filtration using Kiriyama funnel covered with a silica gel thin layer, and the filtrate was evaporated in vacua. The obtained solid was washed with diethyl ether, and dried to give the title compound (16.5 g, 91% yield) as a white solid.

Provenance & Evidence