Styrene-4-sulfonyl chloride → 1-(Tert-butoxycarbonylamino)-4-(4-vinylphenylsulfonyl)-2-piperazinone
Reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)=[CH2:2].C(OC([N:23]1[CH:28]=[CH:27][N:26]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[C:25](=[O:37])[CH2:24]1)=O)C1C=CC=CC=1>>[C:33]([O:32][C:30]([NH:29][N:26]1[CH2:27][CH2:28][N:23]([S:9]([C:6]2[CH:7]=[CH:8][C:3]([CH:1]=[CH2:2])=[CH:4][CH:5]=2)(=[O:11])=[O:10])[CH2:24][C:25]1=[O:37])=[O:31])([CH3:36])([CH3:34])[CH3:35]Participants
3
Procedure
Except for using 4-vinylphenylsulfonyl chloride instead of 6-chloronaphthalene-2-sulfonyl chloride and starting from 4-benzyloxycarbonyl-1-(tert-butoxycarbonylamino)-2-oxo-1,2,3,4-tetrahydropirazine (2.5 g), the process similar to that in Reference Example 5 was employed to obtain the title compound (2.12 g) as a colorless amorphous material.
Sources & evidence
- ORD record
- ord-b1464a81c2b842b3b12407dbaab33c3d
- Source dataset
- uspto-grants-2004_04
- Patent number
- US06723722B1
Reaction notes
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