Hydrochloric Acid → 1-(Pyridin-4-yl)piperidin-4-one

Participants

Reaction Conditions

Reaction Steps

A solution of 8-(4-pyridyl)-1,4-dioxa-8-azaspiro[4.5]decane (172 g) in acetone (700 ml) was combined with 4N hydrochloric acid (700 ml) and stirred at 50° C. for 20 minutes. Acetone was distilled off, and the residue was made alkaline by an addition of an aqueous solution of sodium hydroxide, and then extracted with dichloromethane. After drying and concentrating, the resultant residue was crystallized from ether, collected by filtration and dried to obtain the title compound (119 g) as a pale yellow solid.

Provenance & Evidence