HCID 22727258, compound → 1-Piperazinecarboxylic acid, 3-methyl-5-oxo-, 1,1-dimethylethyl ester

HRID 2086244Notes

Reaction equation

HRID 2086244 reaction equation
C(OC([NH:11][CH:12]([CH3:28])[CH2:13][N:14]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:15][C:16](OCC)=[O:17])=O)C1C=CC=CC=1>CO.[Pd]>[CH3:28][CH:12]1[NH:11][C:16](=[O:17])[CH2:15][N:14]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:13]1

Participants

4

Reactant 1

HCID 22727258HCID 22727258, compound

Product 1

HCID 227270321-Piperazinecarboxylic acid, 3-methyl-5-oxo-, 1,1-dimethylethyl esterYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of ethyl 2-[[2-[[(benzyloxy)carbonyl]amino]propyl](tert-butoxycarbonyl)amino]acetate (2.3 g) and 10% Pd/C (0.23 g) in methanol (46 ml) was stirred at room temperature for 1 hour under a hydrogen atmosphere. The catalyst was filtered off and the filtrate was stirred at 50° C. for 1 hour, concentrated under reduced pressure to obtain the title compound (1.1 g) as a colorless non-crystalline powder.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7854e78de5cf40eab719b63086ad7a40
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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