HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Pyridin-4-yl)piperidin-4-one → (3S)-3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)-4-piperidinylideneamino]-2-pyrrolidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Pyridin-4-yl)piperidin-4-one | HCID 11332793 | — |
| Reactant | (S)-tert-Butyl (1-amino-2-oxopyrrolidin-3-yl)carbamate | HCID 45092234 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (3S)-3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)-4-piperidinylideneamino]-2-pyrrolidone | HCID 69545990 | 111.8% |
Reaction Steps
A solution of (3S)-1-amino-3-(tert-butoxycarbonylamino)-2-pyrrolidone (1.84 g) and 1-(4-pyridyl)-4-piperidone (1.51 g) in ethanol (30 ml) was dehydrated using a Soxlet extractor packed with molecular sieves 4A while refluxing for 15 hours. The reaction mixture was concentrated to obtain (3S)-3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)-4-piperidinylideneamino]-2-pyrrolidone (3.57 g) as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-1c5851ad671f4ecf927a6ace9a2874c1 |
| Source note | uspto-grants-2004_04 |