HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-Chloropyridin-2-yl)methanol | HCID 2763167 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1) | HCID 22727274 | — |
Reaction Steps
A solution of 4-chloro-2-hydroxymethylpyridine (430 mg), thionyl chloride (0.43 ml) and DMF (1 drop) in chloroform (20 ml) was heated under reflux for 2 hours. The reaction mixture was concentrated to obtain the title compound (0.44 g) as a tan powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-3531d839c3e14f35a2bd80a678c857fc |
| Source note | uspto-grants-2004_04 |