HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2086257Generated: November 1, 2026
Sodium Methoxide → 4-Chloro-2-methoxymethylpyridine
https://huagongshe.com/reaction/2086257
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1) | HCID 22727274 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-2-methoxymethylpyridine | HCID 22727092 | 82% |
Reaction Steps
A mixture of 4-chloro-2-chloromethylpyridine hydrochloride (0.43 g), sodium methoxide (1.11 g) and methanol (15 ml) was stirred at room temperature for 10 hours and at 70° C. for 7 hours. The reaction mixture was concentrated, and the residue was combined with water and methylene chloride, and the organic phase was separated. After washing with saturated aqueous sodium bicarbonate followed by drying and concentrating, a title compound (0.28 g) was obtained as a tan oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06723722B1 |
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| Source dataset | uspto-grants-2004_04 |
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| ORD ID | ord-01b252892f29416aba673e6e2f47436c |
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| Source note | uspto-grants-2004_04 |
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