反应详情

A solution of ethyl 4-chloro-6-methylpyridine-2-carboxylate (0.80 g) in methanol (30 ml) was treated at room temperature portionwise with sodium borohydride (1.51 g) and the reaction mixture was heated under reflux for 2 hours. The reaction mixture was concentrated and the resultant residue was combined with water and ethyl acetate, and the organic phase was isolated, dried and concentrated to obtain the title compound (0.60 g) as a tan powder.

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux for 2 hours
3. concentrationThe reaction mixture was concentrated
4. customthe organic phase was isolated
5. customdried
6. concentrationconcentrated