Hydrochloric Acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-{methyl[1-(4-pyridyl)-4-piperidinyl]amino}-2-piperazinone Hydrochloride

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Reaction Steps

A suspension of 4-(6-chloronaphthalene-2-sulfonyl)-1-{methyl[1-(4-pyridyl)-4-piperidinyl]amino}-2-piperazinone (500 mg) in methanol (20 ml) was combined with a 4N solution of hydrochloric acid in ethyl acetate (1 ml) to effect a dissolution, and the solution was concentrated. The residue was crystallized from ethanol/ether, collected by filtration and dried to obtain the title compound (526 mg) as a colorless solid.

Provenance & Evidence