HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 1-{Allyl[1-(4-pyridyl)-4-piperidinyl]amino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | 1-[1-(tert-Butoxycarbonyl)-4-piperidinylamino]-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone | HCID 69545631 | — |
| Product | 1-{Allyl[1-(4-pyridyl)-4-piperidinyl]amino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone | HCID 22727190 | — |
Reaction Steps
Similarly to Method A in Example 38 and using 1-[1-(tert-butoxycarbonyl)-4-piperidinylamino]-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (390 mg) and allyl bromide (2 ml) instead of methyl iodide, the title compound (69 mg) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-ca91a52ce30f450aa0541d2ba23926ab |
| Source note | uspto-grants-2004_04 |