Styrene-4-sulfonyl chloride → HCID 69548714, compound

HRID 2086298Notes

Reaction equation

HRID 2086298 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([NH:14][CH:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[C:10]1=[O:27])=O)(C)(C)C.[CH:28]([C:30]1[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=1)=[CH2:29]>>[N:24]1[CH:23]=[CH:22][C:21]([N:18]2[CH2:17][CH2:16][CH:15]([NH:14][N:11]3[CH2:12][CH2:13][C@H:9]([NH:8][S:36]([C:33]4[CH:34]=[CH:35][C:30]([CH:28]=[CH2:29])=[CH:31][CH:32]=4)(=[O:38])=[O:37])[C:10]3=[O:27])[CH2:20][CH2:19]2)=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 9855777Styrene-4-sulfonyl chlorideHCID 69545831HCID 69545831, compound

Product 1

HCID 69548714HCID 69548714, compoundYield 78.2%

Procedure

Similarly to Example 86 and using (3S)-3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)-4-piperidinylamino]-2-pyrrolidone (220 mg) and 4-vinylbenzenesulfonyl chloride (105 mg), the title compound (179 mg) was obtained as a colorless amorphous material.

Sources & evidence

ORD record
ord-691ed65995904acaaed9727f474c9fb7
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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