7-bromo-2H-benzopyran-3-sulfonyl chloride → HCID 20720843, compound

HRID 2086299Notes

Reaction equation

HRID 2086299 reaction equation
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([NH:14][CH:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[C:10]1=[O:27])=O)(C)(C)C.[Br:28][C:29]1[CH:42]=[CH:41][C:32]2[CH:33]=[C:34]([S:37](Cl)(=[O:39])=[O:38])[CH2:35][O:36][C:31]=2[CH:30]=1>>[Br:28][C:29]1[CH:42]=[CH:41][C:32]2[CH:33]=[C:34]([S:37]([NH:8][C@H:9]3[CH2:13][CH2:12][N:11]([NH:14][CH:15]4[CH2:16][CH2:17][N:18]([C:21]5[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=5)[CH2:19][CH2:20]4)[C:10]3=[O:27])(=[O:38])=[O:39])[CH2:35][O:36][C:31]=2[CH:30]=1

Participants

3

Reactant 2

HCID 219483277-bromo-2H-benzopyran-3-sulfonyl chlorideHCID 69545831HCID 69545831, compound

Product 1

HCID 20720843HCID 20720843, compoundYield 30.5%

Procedure

Similarly to Example 86 and using (3S)-3-(tert-butoxycarbonylamino)-1-[1-(4-pyridyl)-4-piperidinylamino]-2-pyrrolidone (220 mg) and 7-bromo-2H-benzopyran-3-sulfonyl chloride (161 mg), the title compound (87 mg) was obtained as a colorless amorphous material.

Sources & evidence

ORD record
ord-daad76e331904158805f7eace5804b19
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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