HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Pyridin-3-yl)piperidin-4-one → 4-(6-Chloronaphthalene-2-sulfonyl)-1-[1-(3-pyridyl)-4-piperidinylideneamino]-2-piperazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Pyridin-3-yl)piperidin-4-one | HCID 22727051 | — |
| Reactant | 1-Amino-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone | HCID 22727083 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(6-Chloronaphthalene-2-sulfonyl)-1-[1-(3-pyridyl)-4-piperidinylideneamino]-2-piperazinone | HCID 69545632 | 65.3% |
Reaction Steps
Similarly to Example 3, a solution of 1-amino-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (510 mg) and 1-(3-pyridyl)-4-piperidone (260 mg) in toluene (20 ml) was refluxed for 7 hours. The reaction mixture was cooled to room temperature, and the resultant crystal was collected by filtration to obtain the title compound (480 mg) as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-00f90c2a47874184af65b6395071e71c |
| Source note | uspto-grants-2004_04 |