HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Ethylthio)ethylamine hydrochloride → 4-[(6-Chloro-2-naphthyl)sulfonyl]-N-[2-(ethylsulfanyl)ethyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazine Carboxamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Ethylthio)ethylamine hydrochloride | HCID 3016870 | — |
| Reactant | 4-[(6-Chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic Acid | HCID 22727237 | — |
| Product | 4-[(6-Chloro-2-naphthyl)sulfonyl]-N-[2-(ethylsulfanyl)ethyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazine Carboxamide Hydrochloride | HCID 22727255 | 145.5% |
Reaction Steps
Similarly to Example 120 and using 4-[(6-chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic acid (0.18 g) obtained in Example 110 and 2-(ethylthio)ethylamine hydrochloride (0.065 g), the title compound (0.16 g) was obtained as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-b64b30804e5648b98282f5a171f09aab |
| Source note | uspto-grants-2004_04 |