HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → 4-[(6-Chloro-2-naphthyl)sulfonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-(4-thiomorpholinylcarbonyl)-2-piperazinone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 4-[(6-Chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic Acid | HCID 22727237 | — |
| Product | 4-[(6-Chloro-2-naphthyl)sulfonyl]-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-(4-thiomorpholinylcarbonyl)-2-piperazinone Hydrochloride | HCID 22727073 | — |
Reaction Steps
Similarly to Example 116 and using 4-[(6-chloro-2-naphthyl)sulfonyl)-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-6-oxo-2-piperazinecarboxylic acid (0.15 g) obtained in Example 110 and thiomorpholine (0.041 ml), the title compound (0.07 g) was obtained as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06723722B1 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-6441bcd8c0fe433c98cb58947993557f |
| Source note | uspto-grants-2004_04 |